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We aimed to confirm these findings in patients with a BRCA1 or BRCA2 (BRCA1/2) mutation using a tablet. PURPOSE The PAOLA-1/ENGOT-ov25 trial of maintenance olaparib plus bevacizumab for newly diagnosed advanced high-grade ovarian cancer demonstrated a significant progression-free survival (PFS) benefit over placebo plus bevacizumab, particularly in patients with homologous recombination deficiency (HRD)–positive tumors. the phase 3 PAOLA-1 (PAOLA-1/ENGOT-ov25) trial, we evaluated maintenance therapy with a PARP inhibitor (olaparib) as compared with placebo in patients with newly diagnosed ad-Objectives: In the PAOLA -1/ENGOT-ov25 primary analysis (NCT02477644) , adding the PARP inhibitor olaparib to maintenance bevacizumab (bev) after first-line platinum-based chemotherapy. Victor's Predictions and Tips. Their exclusive interface makes it easier to locate the markets where they are quite interested in. Vitibet predictions offer reliable soccer tips to football enthusiasts. 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Progression-free survival (PFS) and second PFS (PFS2) by disease stage in patients (pts) with homologous recombination deficiency (HRD)-positive newly diagnosed advanced ovarian cancer receiving bevacizumab (bev) with olaparib/placebo maintenance in the phase III PAOLA-1/ENGOT-ov25 trial. com eagle predict: best football prediction site in the world | free soccer prediction and tips we are the best free football prediction site in the world. Victor Prediction - Today's Win Tips. They offer you a wide array of correct predictions that you can rely on blindly. Homologous Recombination Repair Gene Mutations to Predict Olaparib Plus Bevacizumab Efficacy in the First-Line Ovarian Cancer PAOLA-1/ENGOT-ov25 Trial. 001), particularly in pts with homologous recombination deficiency (HRD+; BRCA1/2 mutation [BRCAm] and/or genomic instability; Ray. 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They offer you a wide array of correct predictions that you can rely on blindly. In case you are seeking for sites, which predict soccer matches accurately, then king Victor. In case you are seeking for sites, which predict soccer matches accurately, then king Victor. 5. Homologous Recombination Repair Gene Mutations to Predict Olaparib Plus Bevacizumab Efficacy in the First-Line Ovarian Cancer PAOLA-1/ENGOT-ov25 Trial. Homologous Recombination Repair Gene Mutations to Predict Olaparib Plus Bevacizumab Efficacy in the First-Line Ovarian Cancer PAOLA-1/ENGOT-ov25 Trial January 2023 JCO Precision Oncology 7(7):e2200258 PURPOSE The PAOLA-1/ENGOT-ov25 trial of maintenance olaparib plus bevacizumab for newly diagnosed advanced high-grade ovarian cancer demonstrated a significant progression-free survival (PFS) benefit over placebo plus bevacizumab, particularly in patients with homologous recombination deficiency (HRD)–positive tumors. Methods.